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DAY 1: Tuesday 20th of May
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15:00 – 18:00
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Registration
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16:00 - 18:00
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Proteocure MC and CG meeting (open only to members of ProteoCure's Management Committee and Core Group)
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18:00 - 19:30
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Opening Session
Chair: Niki Chondrogianni (National Hellenic Research Foundation, GR), Rosa Farràs (Centro de Investigación Príncipe Felipe, ES) and Olivier Coux (IGMM-CNRS, FR)
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18:00 – 18:30
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Welcome message
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18:30 – 19:30
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THE EMBO KEYNOTE LECTURE
Ubiquitin Proteolytic System: From Basic Mechanisms through Human Diseases and on to Drug Development
Aaron Ciechanover (Technion Israel Institute of Technology, IL)
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19:30 – 21:00
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Welcome reception
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DAY 2: Wednesday 21st of May
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9:00 - 10:10
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Session 1: Quality Control of Protein Biogenesis
Chairs: Michal Sharon (Weizmann Institute of Science, IL)/ Manuel Rodriguez (CNRS, FR)
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9:00 – 9:30
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Keynote Lecture
Altered ubiquitin signaling as an early event in Alzheimer Disease
Michael Glickman (Technion Israel Institute of Technology, IL)
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9:30 – 9:40
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Short talk 1—Jiangnan Liu (Karolinska Institutet, SE) : The EBV deubiquitinase BPLF1 regulates ribosome UFMylaiton and Reticulophagy
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9:40 - 9:50
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Short talk 2—Cristiana C. Santos (Universidade Nova de Lisboa PT): Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signalling
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9:50 – 10:00
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Short talk 3—Wojciech Pokrzywa (International Institute of Molecular and Cell Biology, PL) : Nucleolar plasticity in Stress modulated by protein QC and nucleolar factors
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10:00 - 10:10
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Short talk 4— Mirta Boban (University of Zagreb, HR): Degradation-mediated protein quality control pathways in quiescent cells
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10:10 – 10:45
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Coffee break
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10:45 – 12:30
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Session 2: Ubiquitin & Ubiquitin like modifiers
Chairs: Georgia Chachami (University of Thessaly, GR) / Alfred Vertegaal (Leiden University Medical Center, NL)
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10:45 – 11:15
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Keynote lecture
New strategies to study the role of ubiquitin modifications in development and disease
Rosa Barrio (CIC bioGUNE, ES)
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11:15 - 11:25
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Short talk 5—Maria Blanquer Gárate (Center for Research in Molecular Medicine and Chronic Diseases ES): Regulation of Ubiquitin-like proteins by Mayaro virus NSP2 protease
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11:25 - 11:35
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Short talk 6—Amalia Kanoura (University of Thessaly, GR): The role of TFAP2A and its SUMOylation in hypoxia-dependent transcription
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11:35 - 11:45
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Short talk 7—José Antonio Herrera-Gavilán (Center for Research in Molecular Medicine and Chronic Diseases ES): A SUMO interacting motif in EBOV VP24 protein is required for modulation of PML
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11:45 - 11:55
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Short talk 8—Simona Polo (The AIRC Institute of Molecular Oncology, IT): Beyond the HECT domain: substrate-mediated activation of NEDD4 activity
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12:00 – 12:30
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Flash talks
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12:30 – 13:30
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Lunch break
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13:30 – 14:40
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Session 3: Proteolytic Machinery-Proteasome
Chairs: Elah Pick (University of Haifa, IL), Carmela Giglione (University of Paris-Saclay, FR)
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13:30 – 14:00
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Keynote lecture
Keeping mitochondria in shape: a matter of life and death.
Luca Scorrano (University of Padova, IT)
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14:00 – 14:10
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Short talk 9— Francisco Calderón Celis (University of Oviedo, ES): Quantifying proteolysis efficiency: Unexpected players in action
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14:10 – 14:20
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Short talk 10— Manuel Rodriguez (CNRS, FR): Proteaphagy, a Yin Yang master mechanism regulating sensitivity to bortezomib
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14:20 - 14:30
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Short talk 11—Michal Sharon (Weizmann Institute of Science, IL): Molecular insights into circulating blood Proteasomes
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14:30 - 14:40
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Short talk 12— Marie-Pierre Bousquet (Université de Toulouse, FR): 3rd proteasome inhibitors generation targeting the 20S-activator interface
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14:40 – 16:30
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Poster session
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16:30 - 22:30
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Conference Excursion & Dinner - Visit to Knossos & Dinner at local winery
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DAY 3: Thursday 22nd of May
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9:00 – 10:10
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Session 4: Autophagy/Mitophagy/Lysosomal proteases
Chairs: Heike Laman (University of Cambridge, UK), Carles Galdeano (Universitat de Barcelona, ES)
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9:00 – 9:30
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Keynote lecture
The role of proteasome heterogeneity in the proteostatic network: lessons from rare proteasomopathies
Elke Krüger (University of Greifswald, DE)
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9:30 – 9:40
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Short talk 13— Sophie Rodius (Luxembourg Institut of Health, LU): The transcription factor Hif1α moonlights as a translation modulator
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9:40 - 9:50
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Short talk 14—Colin Adrain (Queen's University Belfast, IE): Role of the ER quality control machinery in lipid homeostasis
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9:50 – 10:00
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Short talk 15— Virag Vincze (HUN-REN Biological Research Centre, HU): Autophagic PIAS/Su(var)2-10 breakdown aids Stat92E activation in reactive glia
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10:00 - 10:10
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Short talk 16—Daniel Taillandier (Université Clermont Auvergne, FR): Blood biomarkers of muscle atrophy correlate with UPS and autophagy genes
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10:10 – 10:45
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Coffee break
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10:45 – 12:30
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Session 5: UPS/Proteases/DUBs
Chairs: Emmanuelle Liaudet-Coopman (INSERM U1194, FR), Mirta Boban (University of Zagreb, HR)
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10:45 – 11:15
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Keynote lecture
Cathepsin S – friend or foe in cancer
Christopher Scott (Queen’s University, Belfast, IE)
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11:15 – 11:25
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Short talk 17— Carles Galdeano (Universitat de Barcelona, ES): Targeting allosteric binding sites in E3 ligases: Novel FBW7 modulators
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11:25 – 11:35
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Short talk 18—Oded Kleifeld (Technion-Israel Institute of Technology IL): Improved proteolysis profiling using C-terminal peptide enrichment
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11:35 – 11:45
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Short talk 19— Thomas Reinheckel (University of Freiburg, DE): Interference of proteases with the oncogenic PI3K-pathway in breast cancer cells
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11:45 - 11:55
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Short talk 20— Vasileios Toulis (Universitat de Barcelona, ES) : Inherited retinal ciliopathies and Proteostasis: What’s USP48 up to?
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11:55 - 12:05
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Short talk 21—Germana Meroni (University of Trieste, IT): TRIM32 E3 ligase controls timely cell cycle exit in muscular differentiation
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12:05 – 12:30
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ELSEVIER PRESENTATION
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12:30 - 13:30
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Lunch break
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13:30 – 15:15
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Session 6: From Bench to Bedside
Chairs: Christine Blattner (Karlsruhe Institute of Technology, DE), Pedro Domingos (Instituto de Tecnologia Química e Biológica António Xavier,PT)
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13:30 – 14:00
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Keynote lecture
Translating translation in neurodegeneration
Giovanna Mallucci (Altos Labs Cambridge Institute of Science, GB)
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14:00 – 14:10
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Short talk 22—Ugo Mayor (University of the Basque Country, ES): Proteomic assessment of UBE3A-mediated Ubiquitination events in the mice brain
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14:10 – 14:20
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Short talk 23—Heike Laman (University of Cambridge, UK): Expression of Fbxo7 restores TH staining in a mouse model of Parkinson's disease
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14:20 - 14:30
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Short talk 24—Rigmor Solberg (University of Oslo, NO): Paracrine roles of the protease legumain in bone and skeletal muscle cells
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14:30 - 14:40
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Short talk 25—Sabine Schipper-Krom (Amsterdam UMC, NL): IDE: A potential therapeutic target for enhancing Huntingtin degradation
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14:45 – 15:15
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Keynote lecture
Modulation of proteostasis by mitochondria-associated mRNA storage and degradation during ageing
Nektarios Tavernarakis (FORTH-IMBB, GR)
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15:15 – 16:00
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Coffee break
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16:00 – 18:30
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Session 6 (cont’d): From Bench to Bedside
Chairs: James D Sutherland (CIC bioGUNE, ES), Nicο Dantuma (Karolinska Institute, SE)
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16:00 – 16:30
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Keynote lecture
Pharmacological exploitation of neurotrophins and their receptors against neurodegeneration: from the bench to the clinic
Ioannis Charalampopoulos (IMBB-University of Crete, GR)
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16:30 – 17:00
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Keynote lecture
Genetic architecture of Parkinson disease on the island of Crete
Cleanthe Spanaki (University of Crete, GR)
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17:00 – 17:10
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STSMs 1—Florence Boon (Ludwig Institute for Cancer Research, BE): Identification of the TAP-independent antigen targeted by a dual T cell receptor
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17:10 – 17:20
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STSMs 2—Oskar Lipiński (Universite Claude Bernard Lyon 1, FR): Structural and biochemical analysis of Mini-Procollagen I C-terminal maturation
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17:20 – 17:30
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STSMs 3—Rachel Havret (University of Barcelona, ES): Development and validation of new inhibitors of heparanase 1
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17:30 – 17:40
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STSMs 4—Javier Antón Salvador (Universidad Politécnica de Valencia, ES): MS-proteomics analysis of FOSL2 knocked-down and over-expressing LUAD cells.
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17:40 – 17:50.
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STSMs 5—Bojan Ilić (University of Belgrade, RS): Alpha-1 antitrypsin effects on proteome of primary skin fibroblasts
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17:50 – 18:00
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STSMs 6—Simon Tack (Ghent University, BE): Shedding light on plant proteolysis: genetically encoded fluorescent sensors
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18:00 – 18:30
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Keynote Lecture
Ligand discovery for understudied proteins
Dalia Barsyte (Structural Genomics Consortium, Toronto, CA)
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18:30 – 19:00
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Discussion: the future COST Action
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DAY 4: Friday 23rd of May
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9:00 – 10:10
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Session 7: Targeting proteolysis - Drug discovery
Chairs: Klaudia Brix (Constructor University, DE), Olivier Coux (IGMM-CNRS, FR)
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9:00 – 9:30
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Keynote lecture
ECM Proteolytic Damage Imprints Perpetuate Chronic Inflammation
Irit Sagi (Weizmann Institute of Science, IL)
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9:30 – 9:40
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Short talk 26— Emmanuelle Liaudet-Coopman (INSERM U1194, FR): Immunotherapy of triple-negative breast cancers with anti-cathepsin D antibodies
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9:40 - 9:50
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Short talk 27— Ivana Novak Nakir (University of Split, HR): Phosphorylation dynamics: Key regulators of receptor-mediated mitophagy
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9:50 - 10.00
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Short talk 28— Wojciech Mądry (Wroclaw University of Science and Technology, PL): A Positional Scanning Approach to Develop Selective Substrates for DUBs
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10:00 - 10:10
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Short talk 29— Tobias Gökler (Technical University of Vienna, AT): Synthesis of Phosphorylated β-catenin N-termini for Structural Investigations
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10:10 – 10:40
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Coffee break
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10:40 – 11:00
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Awarding of poster and short talk prizes (sponsored by FEBS Journal and FEBS Open Bio)
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11:00 – 11:30
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Closing remarks
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